张晗

张晗，副教授

2019年获山东大学化学系博士学位，2019年至2022年在海燕策略线路1功能纳米与软物质研究院从事博士后研究工作。2022年加入海燕策略线路1药学院，被聘为副教授，同年入选“海燕策略线路1优秀青年学者”。

联系方式：hanzhang@suda.edu.cn

研究领域：高分子材料与生物材料；大分子药物递送体系；粘膜相关疾病的局部给药系统；疾病的免疫疗法

主要成果和贡献：

近年来在生物材料与纳米医学领域从事研究。发展了一系列新型的免疫治疗纳米药物，研究了其在抗病毒、抗炎与抗肿瘤等方面的应用；设计构建了多种新型的大分子药物（抗体、细胞因子、酶、核酸等）递送体系，深入研究了其跨屏障递送机制，并探索了其在眼睛、口腔、膀胱等粘膜相关疾病中的应用。在PNAS，ACS Nano，Biomaterials，ACS Sustain. Chem. Eng.，J Colloid Interf. Sci.等期刊发表第一作者论文11篇。主持中国博士后基金面上项目、江苏省博士后科研项目和国家自然科学基金青年科学基金项目共3项。  

代表性论文：

1. Han Zhang, Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, Zhuang Liu*, Inhalable nanocatchers for SARS-CoV-2 inhibition. Proc. Natl. Acad. Sci. U.S.A. 2021, 118, e2102957118.

2. Han Zhang, Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao, Zhishen Xiao, Yanbin Liu, Xianwen Wang, Zhuang Liu, Yang Yang*, Qian Chen*, Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy. Biomaterials 2022, 287, 121673.

3.Han Zhang, Jiafei Zhu, Tianxu Fang, Meng Li, Guojun Chen*, Qian Chen*, Supramolecular biomaterials for enhanced cancer immunotherapy. J. Mater. Chem. B DOI: 10.1039/d2tb00048b

4. Han Zhang, Kai Liu, Shukun Li, Xia Xin*, Shiling Yuan*, Guanghui Ma, Xuehai Yan*, Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy. ACS Nano2018, 12, 8266-8276.

5. Han Zhang, Lei Kang, Qianli Zou, Xia Xin, Xuehai Yan*, Coordination-assembled supramolecular nanoplatforms: structural modulation and theranostic applications. Curr. Opin. Biotech.2019, 58, 45-52.

6. Yuankai Zhang, Han Zhang(Co-first author), Qianli Zou, Ruirui Xing, Tingfeng Jiao, Xuehai Yan*, An injectable dipeptide–fullerene supramolecular hydrogel for photodynamic antibacterial therapy. J. Mater. Chem. B2018, 6, 7335-7342.

7. Han Zhang, Lingyu Guo, Jianmei Jiao, Xia Xin*, Di Sun, Shiling Yuan*, Ionic Self-Assembly of Polyoxometalate Dopamine Hybrid Nanoflowers with Excellent Catalytic Activity for Dyes. ACS Sustain. Chem. Eng.2017, 5, 1358-1367.

8. Han Zhang, Xia Xin*, Jichao Sun, Liupeng Zhao, Jinglin Shen, Zhaohua Song, Shiling Yuan*, Self-assembled chiral helical nanofibers by amphiphilic dipeptide derived from D- or L-threonine and application as a template for the synthesis of Au and Ag nanoparticles. J Colloid Interf. Sci. 2016, 484, 97-106.

9. Han Zhang, Lingyu Guo, Zengchun Xie, Xia Xin*, Di Sun, Shiling Yuan*, Tunable Aggregation-Induced Emission of Polyoxometalates via Amino Acid-Directed Self-Assembly and Their Application in Detecting Dopamine. Langmuir2016, 32, 13736-13745.

10. Han Zhang, Menghong Yu, Aixin Song, Yawen Song, Xia Xin*, Jinglin Shen, Shiling Yuan*, Modulating hierarchical self-assembly behavior of a peptide amphiphile/nonionic surfactant mixed system.RSC Adv. 2016, 6, 9186-9193.

11. Han Zhang, Jichao Sun, Xia Xin*, Wenlong Xu, Jinglin Shen, Zhaohua Song, Shiling Yuan*, Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system. J Colloid Interf. Sci.2016, 467, 43-50.